Each capsule provides: %NRV*
Saffron 4:1Extract (equivalent to 200mg of Saffron providing 1mg of Safranol and 3.50mg of Crocin) 50mg **
*NRV=Nutrient reference value
** = No nutrient reference established
Ingredients: Brown Rice Flour (Bulking Agent), Hydroxypropyl Methylcellulose (HPMC) Capsule Shell(Vegetarian), Saffron 4:1 Extract, Magnesium Stearate (Vegetarian) (Flowing Agent). Suitable for vegetarians.
Guidelines for best results:
Take 1 capsule 60 minutes before main meals with a full glass of water
For best results take 2 capsules a day with main meals.
Do not exceed recommended dose
Take 2 capsule a day.
Supplements should not be used to replace a balanced diet and lifestyle .
If you are under 18, pregnant, breastfeeding or taking any medications, consult a doctor before use.
Discontinue use and contact your doctor immediately in the event of an adverse reaction.
Not intended for persons under the age of 18.
These statements have not been evaluated by the Food and Drug Association. This is not intended to diagnose, treat, cure or prevent any disease.
Keep out of direct sunlight in a cool dry place out of sight and reach of children
Do not use if inner seal is damaged
For best before date see base
Clinical Studies: Key Findings from the Saffron studies
Key findings from the saffron studies:
Saffron extract improved snacking 55% compared to 28% placebo
Saffron extract decreased appetite 84% compared to 52% placebo
Saffron extract decreased urge for sugary snacks 78% compared to 46% placebo
Statistically significant reduction in body weight in Saffron extract group ( -2.11 lbs vs 0 in placebo group)
Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.
60 mildly overweight females participated in this placebo controlled, double blind, randomized clinical trial. Body weight measurements were made over an 8 week period. 31 subjects received Saffron (176mg/day), 29 subjects received placebo. After 8 weeks, the mean snacking frequency was significantly decreased in the Saffron group versus the placebo group (p <0.05).
Saffron extract improved snacking 55% compared to 28% placebo.
Saffron extract decreased appetite 84% compared to 52% placebo.
Saffron extract decreased urge for sugary snacks 78% compared to 46% placebo.
Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation.
Saffron extract improved ethanol-induced impairments of learning behaviours in mice, and prevented ethanol-induced inhibition of hippocampal long-term potentiation, a form of activity-dependent synaptic plasticity that may underly learning and memory. This effect of saffron extract is attributed to crocin (crocetin di-gentiobiose ester), but not crocetin. Saffron extract or its active constituents, crocetin and crocin, could be useful as a treatment for neurodegenerative disorders accompanying memory impairment
Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines.
In this study cytotoxic effect of saffron extract was evaluated in HepG2 and HeLa cell lines. Meanwhile role of apoptosis and ROS were explored. Malignant and non-malignant cells (L929) were cultured in DMEM medium and incubated with different concentrations of ethanolic saffron extract.
Saffron could decrease cell viability in malignant cells as a concentration and time-dependent manner. The IC50 values against HeLa and HepG2 were determined 800 and 950 microg/ml after 48 h, respectively. Saffron induced a sub-G1 peak in flow cytometry histogram of treated cells compared to control indicating apoptotic cell death is involved in saffron toxicity. It might be concluded that saffron could cause cell death in HeLa and HepG2 cells, in which apoptosis or programmed cell death plays an important role. Saffron could be also considered as a promising chemotherapeutic agent in cancer treatment in future.
Further examination of antiradical properties of Crocus sativus stigmas extract rich in crocins.
Data for antiradical properties of saffron extract and its bioactive constituents (crocins, crocetin) are limited and poorly discussed in comparison with those of extracts containing potent scavengers.
In the human monocyte system, saffron extracts or free crocetin were found to reduce ROS production as effectively as the phenolic antioxidants. Our findings point out that saffron extracts exhibit a remarkable intracellular antioxidant activity that cannot be revealed using assays repeatedly applied to the evaluation of phenolic-type antioxidants.